Meller Group : Single Molecule Biophysics & Nano-biotechnologyTechnion Logo

336538 Single molecule approaches for biophysics and bioengineerin
עקרונות ביו-פיזיקליים וביו-הנדסיים לחישת מולקולות בודדות


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Single molecule approaches for biophysics and bioengineering – Fundamentals and Applications

The emergence of single-molecule methods in biology and bioengineering in the past decade have revolutionized the way scientists approach the molecular biology of the cell. The ability to directly probe biomolecular processes in real-time and in their native cellular environment can be used to unravel the mechanism of fundamental biological processes with unprecedented detail and accuracy. As single-molecule methods are refined, they are increasingly recruited by bioengineers to pave future platforms for molecular diagnostics and analytical detection.

This course covers experimental methods for investigating the molecular machinery of the cell used both in vitro and in live cells. Additionally, the course covers novel tools for sensing biomolecules and their applications in biotechnology. Fundamental principles underlying fluorescence of single molecules, force measurements of biomolecules, ion channel kinetics and stochastic sensing will be covered all in contextual relevance with biological and biotechnological examples. Emphasis will highlight fundamental physical concepts underlying these systems, essentially from the field of statistical mechanics of soft matter.